Document Type
Article
Source Publication Title
General Hospital Psychiatry
Abstract
Objective
This systematic review synthesized evidence on the cost-effectiveness and economic favorability of interventions for the detection, treatment, and prevention of perinatal mood and anxiety disorders (PMADs).Methods
This protocol is registered on PROSPERO (CRD42024528777). PubMed, EMBASE, Web of Science, EconLit, Scopus, PsycINFO, and the National Health Service economic evaluation databases were searched from inception through April 2025. Intervention studies reporting quality-adjusted life years, incremental cost-effectiveness ratios, or equivalent cost analyses during pregnancy or up to one year postpartum were included. Risk of bias was assessed using the Consensus on Health Economics Criteria and Bias in Economic Evaluation checklists. Data were synthesized by study design, intervention type, and economic perspective.Findings
The search identified 3863 records; 1820 deduplicated titles and abstracts, and 75 full texts were assessed for eligibility. Thirty-seven studies were included (n = 218,525 participants). Thirty-two (86.5 %) interventions were cost-effective or economically favorable, including prevention-only (28.1 %), treatment-only (34.3 %), screening-only (18.7 %), and screening plus treatment and/or prevention (18.7 %). Cost-effective evaluations were primarily from the healthcare system (46.8 %) or payer (25 %) perspectives. Twenty-two (68.7 %) cost-effective interventions included time horizons of one year or greater. Five of six (83.3 %) non-cost-effective interventions included time horizons of less than one year. Studies were heterogeneous in design, population, and intervention types.Interpretation
Findings support the integration of PMAD interventions into perinatal clinical care. Evidence-based policy and payment models are needed for scaling sustainable uptake. Research priorities include standardization in economic evaluation methods, longer-term modeling, and inclusion of diverse populations.First Page
253
Last Page
274
DOI
https://doi.org/10.1016/j.genhosppsych.2025.11.005
Publication Date
11-2025
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Alam, Sabrina; Christman, Brian; McNeill, Emma; Tang, Man; Rong, Rong; Li, Qing; Hillegass, William; Hall, Janice; Wright, Laura; Lanier, Chisa; Xiong, Xu; Shi, Lizheng; and Gamble, Abigail, "Economic evaluation of screening, treatment, and prevention interventions for perinatal mood and anxiety disorders: a systematic review" (2025). Preventive Medicine Publications. 1.
https://digitalcollections.umc.edu/preventivemedicinepub/1
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